I would still like Ascendacy feel way more impactful. You should feel like your going ssj1 after the initial ascendacy. Even if they have to nerf things on the front or back end to balance. The initial boost should feel amazing imo. Currently I don't even bother going past 2 or 3 ascendacy for my characters. Not worth the effort or irritation.
Next, the uniques still suck or completely unusable. Most need a buff and negative effects removed. Meta is rolling best possible rare 90% of the time and that's just boring. If they could introduce sets would be fun down the road as well.
Other then that just the end game updates and finish the base game would be great. Want remaining classes even if not perfect yet. Just get them out there.