Giant's blood is really tanking your life total. I'm not sure it's worth clicking at all after the nerf since strength stacking is so important for life. You would instantly gain over 400 life by getting rid of it.
Ideally you want t1 or t2 life on every piece of gear and high tier strength as much as possible, though this will be harder because you are using so many unique items. You have really good strength but Giant's Blood is halving the life it gives you.
12k armor is also a really low amount, and I notice you have armor increases set to weapon set passives, meaning they will deactivate frequently. Most importantly though, your gear just prioritizes damage over defense. It will be hard to get more armor with your setup, but you could swap gloves, rings, boots, and amulet for ones with life and strength (or try to look for t1 life on amulet by re-desecrating).
You could also look to invest more in block instead of armor to increase ehp, but this wont solve the max hit problem without getting more life on gear. Like others have said, definitely pick up 15% more life through Mysterious Lineage ascendancy.
Pretty different build because I played Shield Wall this season but here's my 98 Titan if it would help to look at gear: https://poe.ninja/poe2/profile/UrNan-4827/character/twohundredthousandrats