Play the league (fate of the vaal). Don't play solo self found (can't trade), or of the hardcore versions (can't die). Every league lets you play the story. In fact, unlike in D4, you have to play the story with every league and new character.
Play any class that looks fun. They all naturally kind of play exactly as they look. Ranger does arrows, Witch does necromancy and blood, Sorc uses elemental magic, etc.
One of the major differences between D4 and POE2 is any classes clan play in the style of any of any other classes, this leads to interesting interactions.
If you want to see the meta its on poe.ninja, but its mostly about the endgame. All classes can beat all endgame content.
melee has a marginally harder time in the story then ranged characters, but just marginal.
Also, you can't really brick your character in poe2. Anything can be respecced except for base class, but like I said, even that can be worked into any playstyle.
Don't be afraid to ask future questions here, plenty of helpful people.